Light-Sensitive Polymeric Nanoparticles Based on Photo-Cleavable Chromophores (Springer Theses) Hardcover

The triggered release of functional compounds from such polymeric carriers as
micelles, nanoparticles or nanogels is a rapidly developing and highly
versatile concept which is expected to be one of the key approaches to future
therapeutics. In his thesis, Daniel Klinger highlights the approach of
stimuli-responsive microgels for such applications and discusses why
especially light as a trigger has an outstanding position amongst the family
of conventional stimuli. Based on these considerations, the author focuses on
the design, synthesis and characterization of novel photo-sensitive microgels
and nanoparticles as potential materials for the loading and light-triggered
release/accessibility of functional compounds. Starting from the synthesis of
photo-cleavable organic building blocks and their use in the preparation of
polymeric nanoparticles, continuing to the examination of their loading and
release profiles, and concluding with biological in vitro studies of the final
materials, Daniel Klinger’s work is an excellent example of the
multidisciplinary research needed for the successful development of new
materials in this field and has led to a number of further publications in
internationally respected journals. Read more

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