Immuno Defense 4x is an immune-supporting formula that has
the unique ability of providing a specialized dried whole-food fermentate that
is a high metabolite immunogen. It also supports strong cellular metabolism
while supporting immune health. This specialized whole-food fermentate call
EpiCor helps to influence that processes that impact immune health in a
positive way. Combine this with the sunshine vitamin which research is showing
has the ability to attach to immune cells and provide a boost to both innate
and adaptive immunity within the body. Each nutrient can act independently to
support immune health—but this powerful combination works in unison to build a
protective layer around the body. Better than just Vitamin C, Echinacea or
Elderberry. Here Is What Is In Immuno Defense 4x EpiCor Specialized dried
whole-food fermentate that is a high metabolite immunogen. It also supports
strong cellular metabolism while supporting immune health. Quercetin A natural
antioxidant found in many foods—including DARK CHOCOLATE. Quercetin works to
balance an overactive immune system, so the immune system can function like
normal. Vitamin D3 Current research shows it could be the missing link to a
stronger immune system. It activates the immune cells by attaching to
them—giving a boost to the innate and adaptive immunity. Bromelain This enzyme
found in the flesh, skin, and juice of pineapples, is the one nutrient that
ties all of these ingredients together. It can lower inflammation in nasal
passages to make breathing easier—and improves the absorption of all 3
nutrients included in this formula. Read more References/Citations 1. Hemila
H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane
Database Syst Rev. 2013 Jan 31; (1): CD000980. 2. Douglas RM, Chalker EB,
Treacy B. Vitamin C for preventing and treating the common cold. (updated).
Cochrane Database Syst Rev. 2014 Oct 18;(4):CD00980. 3. Jensen GS, Patterson
KM, Barnes J, Schauss AG, Beaman R, Reeves SG, Robinson LE. A Double-Blind
Placebo-Controlled, Randomized Pilot Study: Consumption of a High-Metabolite
Immunogen from Yeast Culture has Beneficial Effects on Erythrocyte Health and
Mucosal Immune Protection in Healthy Subjects. The Open Nutrition Journal.
2008;2:68-75. 4. Moyad MA, Robinson LE, Zawada Jr. ET, Kittelsrud JM, Chen DG,
Reeves SG, Weaver SE. Effects of a modified yeast supplement on cold/flu
symptoms.. Urol Nurs. 2008 Feb;28(1):50-5. 5. Moyad MA, Robinson LE, Zawada
ET, Kittelsrud J, Chen DG, Reeves SG, Weaver S. Immunogenic Yeast-Based
Fermentate for Cold/Flu-like Symptoms in Nonvaccinated Individuals. J Altern
Complement Med. 2010 Feb 1;16(2):213-218. 6. Moyad MA, Robinson LE, Kittelsrud
JM, Reeves SG, Weaver SE, Guzman AI, Bubak ME. Immunogenic yeast-based
fermentation product reduces allergic rhinitis-induced nasal congestion: a
randomized, double-blind, placebo-controlled trial. Adv Ther. 2009
Aug;26(8):795-804. 7. Jensen GS, Redman KA, Benson KF, Carter SG, Mitzner MA,
Reeves S, Robinson L. Antioxidant bioavailability and rapid immune-modulating
effects after consumption of a single acute dose of a high-metabolite yeast
immunogen: results of a placebo-controlled double-blinded crossover pilot
study. J Med Food. 2001 Sep;14(9):1002-10. 8. Punheiro I, Robinson L, Verhelst
A, Marzorati M, Winkens B, Van den Abbeele P, Possemiers S. A yeast fermentate
improves gastrointestinal discomfort and constipation by modulation of the gut
microbiome: results from a randomized double-blind placebo-controlled pilot
trial. BMC Complement Altern Med. 2017 Sep 4;17(1):441. 9. 6. Jensen, G. S.;
Carter, S. G.; Reeves, S. G.; Robinson, L. E.; Benson, K. F., Anti-
Inflammatory Properties of a Dried Fermentate In Vitro and In Vivo. J Med Food
2014. 10. Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Lui H, Yin Y.
Quercetin, Inflammation, and Immunity. Nutrients. 2016 Mar;8(3):167. 11. Mlcek
J, Jurikova T, Skrovankova S, Sochor J. Quercetin and Its Anti-Allergic Immune
Response. Molecules. 2016 May;21(5):632. 12. Yu YL, Cheng WC, OuYang CN, Fu E,
Chu CL. Immunosuppresive Effect of Quercetin on Dendritic Cell Activation and
Function. The Journal of Immunology. 2-6821. 13. Wong G, He S,
Siragam V, Br Y, Mbikay M, Chretien M, Qiu X. Antiviral activity of quercetin
3-β-O-D-glucoside against Zika virus infection. Virol Sin. 2017
Dec;32(6):545-547. 14. Gaudry A, Bos S, Viranaicken W, Roche M, Kerjbich-
Trotot P, Gadea G, Depres P, El-Kalamouni C. The Flavonoid Isoquercitrin
Precludes Initiation of Zika Virus Infection in Human Cells. Int J Mol Sci.
2018;19(4):1093. 15. Munjal A, Khandia R, Dhama K, Sachan S, Karthik K, Tiwari
R, Malik YS, Kumar D, Singh RK, Iqbal HMN, Joshi SK. Advances in Developing
Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives.
Microbiol Aug 3 2017. 16. Lima CS, Caruso IP, Araujo GC, Hirokubo L, Lacove R,
Falcon M, Desideri A, Oliveira J, Regsaini LO, Souza FP, Toledo KA. Quercetin
pentaacetate inhibits in vitro human respiratory syncytial virus adhesion.
Virus Research Jan 205. 17.Qiu X, Kroeker A, He S, Kozak R, Audet
J, Mbikay M, Chretien M. Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside
against Ebola Virus Infection. Antimicrob Agents Chemother. 2016
Sep;60(9):5182-5188. 18. Farazuddin M, Mishra R, Jing Y, Srivastava V,
Comstock AT, Sajian US. Quercetin prevents rhinovirus-induced progression of
lung disease in mice with COPD phenotype. PLoS One. 2018;13(7):e0199612. 19.
Wu W, Li R, Li X, Ho J, Jiang S, Liu S, Yang J. Quercetin as an Antiviral
Agent Inhibits Influenza A virus (IAV) Entry. Viruses. 2016 Jan;8(1):6. 20.
Hosseinzade A, Sadeghi O, Biregani AN, Soukhtehzarl S, Brandt GS, Esmaillzadeh
A. Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+
Regulatory Cells Through Suppression of MTOR Pathway Signaling Activitiy.
Front Immunol. 2019 Jan 31. 21. Aranow C. Vitamin D and the Immune System. J
Investig Med. 2011 Aug;59(6):881-886. 22. Prieti B, Treiber G, Pieber TR,
Amrein K. Vitamin D and Immune Function. Nutrients. 2013 Jul;5(7):2502-2521.
23. Medrano M, Carrillo-Cruz E, Montero I, Perez-Simon JA. Vitamin D: Effect
on Haematopoiess and Immune System and Clinical Applications. Int J Mol Sci.
2018 Sep;19(9):2663. 24. Braun M, Schneider B, Beuth HJ. Therapeutic use
efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in
children with acute sinusitis in Germany. In vivo. 2005;19:417-421. 25.
Rathnavelu V, Alitheen NB, Sohila S, Kanagesan S, Ramesh R. Potential role of
bromelain in clinical therapeutic applications. Biomed Rep. 12016
Sep;5(3):283-288. 26. Engwerda CR, Andrew D, Ladhams A, Mynott TL. Bromelain
Modulates T Cell and B Cell Immune Responses in vitro and in vivo. Cellular
Immunology. 2001 May;210(1):66-75. 27. Nuttner L, et al. Efficacy and
tolerability of bromelain in patients with chronic rhinosinusitis—a pilot
study. B-ENT. 2013;9(3):217-25. 28. Guo R, Canter PH, Ernst E. Herbal
medicines for the treatment of rhinosinusitis: a systematic review.
Otolaryngol Head Neck Surg. 22006 Oct;35(4):496-506. 28. Ginde AA, Mansbach
JM, Camargo CA., Jr. Association between serum 25-hydroxyvitamin D level and
upper respiratory tract infection in the Third National Health and Nutrition
Examination Survey. Arch Intern Med. 2009;169(4):384–90. 29. Laaksi I, et al.
An association of serum vitamin D concentrations < 40 nmol/L with acute
respiratory tract infection in young Finnish men. Am J Clin Nutr.
2007;86(3):714–7.
Features:
- Supports A Healthy Immune System*
- Clinically shown to activate NK (Natural Killer) cell activity within two hours of ingestion*
- Helps To Beneficially Balance The Immune Response*
- Helps To Strengthen The Mucosal Immune Barrier
- Helps To Strengthen Innate Immunity & Adaptive Immunity